Reversible conduction block in peripheral nerve using electrical waveforms

Toward a Selective, Reversible Optigenetic Block of Peripheral Nerve Conduction

As much as 8% of the general population suffers from chronic pain of a neuropathic origin. Peripheral neuropathic pain arises from damage to peripheral sensory nerves. Hypersensitization and increased spontaneous signaling in pain fibers have been shown to occur in damaged afferent nerves, resulting in episodes of chronic, persistent pain in absence of actual nociceptive stimuli. Small, unmyeli...

Title : Differential fiber - specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation

Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation.

Kilohertz electrical stimulation (KES) has been shown to induce repeatable and reversible nerve conduction block in animal models. In this study, we characterized the ability of KES stimuli to selectively block specific components of stimulated nerve activity using in vivo preparations of the rat sciatic and vagus nerves. KES stimuli in the frequency range of 5-70 kHz and amplitudes of 0.1-3.0 ...

Challenges associated with nerve conduction block using kilohertz electrical stimulation.

Neuromodulation therapies, which electrically stimulate parts of the nervous system, have traditionally attempted to activate neurons or axons to restore function or alleviate disease symptoms. In stark contrast to this approach is inhibiting neural activity to relieve disease symptoms and/or restore homeostasis. One potential approach is kilohertz electrical stimulation (KES) of peripheral ner...

Innovative Methodology Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation

Patel YA, Butera RJ. Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation. J Neurophysiol 113: 3923–3929, 2015. First published April 15, 2015; doi:10.1152/jn.00529.2014.—Kilohertz electrical stimulation (KES) has been shown to induce repeatable and reversible nerve conduction block in animal models. In this study, we charac...